CPH-2011

Learning Objectives

1. This module deals with the principles of neuropharmacology and the covers various aspects of how different classes of drugs affect the brain. Various neurotransmitter systems are discussed together with the interaction of drugs on the various neurophysiological processes involved in brain function.

2. To understand the basic pharmacology and mode of action of drugs used to treat disorders associated with the cardiovascular system

3. review of drugs that affect blood and blood forming organs; haematopoiesis and blood coagulation; drugs used in endocrine disorders.

 Content 

• Classification of the nervous system and the role of the blood brain barrier

• Nerve cells and neural communication: neurons and glial cells

• Electrical properties of neurons: generation and conduction of nerve impulse

• Action potential; ion channels; synaptic transmission

• Receptors: ionotropic and metabotropic receptors. Agonists and antagonists; Neurotransmitters. Pharmacological intervention on various neurotransmitter pathways

• Methods of studying the nervous system. Pharmacological methods.

• Drugs affecting cholinergic transmission. The role of acetylcholine

• Drugs affecting major inhibitory neural transmissions: GABA and glycine

• Serotonin and dopamine. Pharmacological intervention in diseases involving higher cognitive functions; Excitatory neurotransmission: drugs acting on glutamate and the NMDA receptor; Neuropeptides

• Noradrenergic transmission. Adrenoreceptor agonists and antagonists

• Relevant physiology and anatomy of cardiac function and circulation

• Beta and alpha blockers; calcium antagonists

• Centrally acting drugs and vasodilators

• Ace inhibitors; diuretics; nitrates and cardiac inotropes

• Antiarrythmic drugs and thrombolytics and anticoagulants

• Lipid lowering drugs; Drugs acting on blood and blood forming organs e.g. Iron, vitamin B₁₂, folic acid;Coagulation disorders, Vitamin K, Warfarin and heparin

• Anti-platelet drugs and fibrinolytic agents

Type

Lectures, seminars, assignments and credit test.

Assessment

In the continuous and final mode:  i.e. continuous assessments and final credit test at end of study unit

Result

Percentage mark and grade.

Lecturers

Professor F.F. Fenech
Dr. Charles Scerri